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Cat. No. Product Name Target Signaling Pathways
T3977 Lifitegrast

SHP-606,SAR 1118,立他司特,利非司特

Integrin Cytoskeletal Signaling
Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂, 抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。
T7423 Diquafosol tetrasodium

地夸磷索四钠,INS365

P2Y Receptor GPCR/G Protein; Neuroscience
Diquafosol tetrasodium (INS365) 是一种 P2Y2 受体激动剂,可刺激眼组织粘蛋白的分泌。它可改善泪膜稳定性和视觉功能,作为干眼症的局部治疗。
T28496 R-932348 choline

R-932348,R 348,R 932348,R932348,R-348,R348

R-932348 choline, a dual JAK/SYK inhibitor, is used potentially for treatment of dry eye disease.
T39293 Tivanisiran

SYL1001,Tivanisiran

Tivanisiran (SYL1001) is a siRNA developed specifically to inhibit the expression of transient receptor potential vanilloid 1 (TRPV1) to explore its implications in dry eye disease research.
T70346 TOP1362

TOP1362 is a Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders. TOP1362 strongly inhibited the kinase targets p38α, Syk, Src, and Lck, blocked the rise in p38α expression in hyperosmolar Chang cells, and potently reduced inflammatory cytokine release in cellular models of innate and adaptive immunities. In the EIU model, TOP1362 dose-dependently attenuated the LPS-induced rise in inflammatory cell infiltration and o...
T79235 JAK-IN-30

JAK Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
JAK-IN-30(化合物31)是一种具有水溶性的JAK抑制剂,对JAK2、JAK1、JAK3及TYK2的IC50值分别为2、15、18及2 nM。该化合物作为研究干眼症(DED)的潜在药物而备受关注。

化合物

Lifitegrast
Cat.No: T3977
Synonym: SHP-606,SAR 1118,立他司特,利非司特
Target: Integrin
Diquafosol tetrasodium
Cat.No: T7423
Synonym: 地夸磷索四钠,INS365
Target: P2Y Receptor
R-932348 choline
Cat.No: T28496
Synonym: R-932348,R 348,R 932348,R932348,R-348,R348
Target:
Tivanisiran
Cat.No: T39293
Synonym: SYL1001,Tivanisiran
Target:
TOP1362
Cat.No: T70346
Synonym:
Target:
JAK-IN-30
Cat.No: T79235
Synonym:
Target: JAK
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